Lupeol

• Description :

  Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) [1].

• Product Name Alternative :

  Clerodol; Monogynol B; Fagarasterol

• UNSPSC :

  12352211

• Hazard Statement :

  H302

• Target :

  Androgen Receptor; Apoptosis

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Lupeol.html

• Purity :

  98.0

• Solubility :

  DMSO : 2 mg/mL (ultrasonic) |Ethanol : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C[C@]1([C@@]2(CC[C@@]3([H])C4(C)C)C)[C@@](CC[C@]2([H])[C@]3(CC[C@@H]4O)C)([H])[C@]([C@@H]5C(C)=C)([H])[C@](C)(CC5)CC1

• Molecular Formula :

  C30H50O

• Molecular Weight :

  426.72

• Precautions :

  H302

• References & Citations :

  [1]Siddique HR, et al. Lupeol, a novel androgen receptor inhibitor: implications in prostate cancer therapy. Clin Cancer Res. 2011 Aug 15;17 (16) :5379-91.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [545-47-1]