A 779

• Description:

  A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII.

• UNSPSC:

  12352209

• Target:

  Angiotensin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/A_779.html

• Purity:

  99.12

• Solubility:

  DMSO : 18.18 mg/mL (adjust pH to 2 with 1 M HCl)

• Smiles:

  O=C (N[C@] ([C@@H] (C) CC) ([H]) C (N[C@H] (C (N[C@H] (C) C (O) =O) =O) CC1=CNC=N1) =O) [C@@H] (NC ([C@H] (C (C) C) NC ([C@H] (CCCNC (N) =N) NC ([C@@H] (N) CC (O) =O) =O) =O) =O) CC2=CC=C (O) C=C2

• Molecular Formula:

  C39H60N12O11

• Molecular Weight:

  872.97

• References & Citations:

  [1]Abuohashish HM, et al. Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axis. Sci Rep. 2017 May 23;7 (1) :2293.|[2]Abuohashish HM, et al. ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats. Biomed Pharmacother. 2017 Aug;92:58-68.|[3]Yan WF, et al. Effects and related mechanism of angiotensin- (1-7) on Toll-like receptor 4-mediated oxidative stress in human umbilical vein endothelial cells. Zhonghua Xin Xue Guan Bing Za Zhi. 2017 Mar 24;45 (3) :223-229.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  AT1 Receptor; AT2 Receptor

• CAS Number:

  159432-28-7