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Befotertinib

CAT: 0804-HY-137433-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137433-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Befotertinib (D-0316) is an orally active EGFR tyrosine kinase inhibitor. Befotertinib can inhibit the proliferation of tumor cells. Befotertinib can be used in the research of EGFR T790M-positive non-small cell lung cancer (NSCLC) [1][2].
CAS Number
1835667-63-4
Product Name Alternative
D-0316
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/befotertinib.html
Purity
99.86
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC(NC2=NC(C3=CN(CC(F)(F)F)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CCN(C)C)C)OC)C=C
Molecular Formula
C29H32F3N7O2
Molecular Weight
567.61
References & Citations
[1]Nagasaka M, et, al. Beyond Osimertinib: The Development of Third-Generation EGFR Tyrosine Kinase Inhibitors For Advanced EGFR+ NSCLC. J Thorac Oncol. 2021 May;16 (5) :740-763.|[2]Blair HA. Befotertinib: First Approval. Drugs. 2023 Oct;83 (15) :1433-1437.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4

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BA6345-1Befotertinib
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A24177-10Befotertinib mesylate (D-0316 mesylate) 10mg
A24177-5Befotertinib mesylate (D-0316 mesylate) 5mg
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