LDHA Polyclonal Antibody

CAT: 0763-D-AB-10210L-01Size: 25 µLDry Ice: NoHazardous: No

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CAT#:0763-D-AB-10210L-01Size:25 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

LDHA, also named as LDH-M and NY-REN-59, is an enzyme which catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria. LDHA has some isoforms with MW 26-40 kDa.

Abbreviation

LDHA

UniProt

P00338

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Human LDHA protein expressed by E.coli

Target

Cell proliferation-inducing gene 19 protein; GSD11; L lactate dehydrogenase A chain; l7R2; LDH M; LDH muscle subunit; LDH1; PIG19 Proliferation-inducing gene 19

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Metabolism; Signal Transduction

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:2500-1:5000; IHC 1:200-1:400

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

26,30,36,39 kDa

Observed Molecular Weight

36 kDa

Isotype

IgG

UniProtKB · P00338

L-lactate dehydrogenase A chain

LDHA_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P00338
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: LDHA
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: LDH-A
EC number: 1.1.1.27
Processing: —
Secondary accessions: B4DKQ2, B7Z5E3, D3DQY3, F8W819, Q53G53, Q6IBM7, Q6ZNV1, Q9UDE8, Q9UDE9

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Disease

Disease variantGlycogen storage disease

Ligand

NAD

Molecular function

Oxidoreductase

Product Datasheet

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