Monoethylglycinexylidide (hydrochloride)

Monoethylglycinexylidide (hydrochloride)

• CAS Number: 7729-94-4
• UNSPSC Description: Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation[1][2].
• Target Antigen: Drug Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/monoethylglycinexylidide-hydrochloride.html
• Purity: 98.82
• Solubility: 10 mM in DMSO
• Smiles: CCNCC(NC1=C(C)C=CC=C1C)=O.Cl
• Molecular Weight: 242.75
• References & Citations: [1]Huang YS, et al. Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis. J Hepatol. 1993 Aug;19(1):140-7.|[2]Esen F, et al. Monoethylglycinexylidide (MEGX) as an early predictor of liver dysfunction in severe sepsis. Critical Care, 1997, 1(Suppl 1):P083.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported