YH-306

CAT: 0804-HY-120213-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120213-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization[1].
CAS Number
[1373764-75-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; FAK; MMP; PI3K; Src
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yh-306.html
Purity
98.34
Solubility
DMSO : 20 mg/mL (ultrasonic; adjust pH to 1 with HCl)
Smiles
OC1=CC=C(C=C1)CC(N2CC(NC3=C4C=CC=C3)=C4CC2)=O
Molecular Formula
C19H18N2O2
Molecular Weight
306.36
Precautions
H302, H315, H319
References & Citations
[1]Dai F, et al. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2015 Feb;19 (2) :383-95.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-2; MMP-9; PI3K

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