Guanosine 5'-triphosphate (trisodium salt)

Guanosine 5'-triphosphate (trisodium salt)

• Alternative Name: 5'-GTP (trisodium salt)
• CAS Number: 36051-31-7
• UNSPSC Description: Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1][2].
• Target Antigen: DNA/RNA Synthesis; Endogenous Metabolite
• Type: Natural Products
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/5_acute_-GTP-trisodium-salt.html
• Purity: 99.76
• Solubility: H2O : 125 mg/mL (ultrasonic)
• Smiles: O=P(OP(OP(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)=O)([O])=O)(O[Na])O[Na].[Na]
• Molecular Weight: 589.13
• References & Citations: [1]Guanosine triphosphate.|[2]Pietrangelo T, et al. Extracellular Guanosine 5'-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine. Front Pharmacol. 2018 Mar 16;9:152.Anal Chim Acta. 18 October 2021, 339180.|Mol Cell. 2022 Apr 14:S1097-2765(22)00290-8.|Acta Pharm Sin B. 2023 Dec 14.|J Mol Biol. 2024 Mar 4:168513.|Bioorgan Med Chem. 2021 Jan 1;29:115899.|bioRxiv. 2024 Apr 24.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen, away from moisture)
• Clinical Information: Phase 3