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L-669083

CAT: 0804-HY-118197Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118197Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-669083 is a leukotriene biosynthesis inhibitor whose structure is based on a mixture of indole and quinoline. In this study, a potent radioiodinated photoaffinity analog of L-689,037, [125I] L-691,678, was developed and characterized for immunoprecipitation studies showing that the quindole series of leukotriene biosynthesis inhibitors directly interact with FLAP. In addition, the results showed that MK-886, L-674,573, and L-689,037 competed with [125I] L-691,678 and [125I] L-669083 for binding to FLAP in a concentration-dependent manner, indicating that these three leukotriene biosynthesis inhibitors share a binding site on FLAP, further demonstrating that FLAP is a suitable target for structurally diverse leukotriene biosynthesis inhibitors.
CAS Number
130007-52-2
UNSPSC
12352005
Target
FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-669083.html
Smiles
[N-]=[N+]=NC1=CC=C(S(=O)(C2=C(CC(C)(C)C(O)=O)N(CC3=CC=C(C(I)=C3)O)C4=C2C=C(C(C)C)C=C4)=O)C=C1
Molecular Formula
C29H29IN4O5S
Molecular Weight
672.53
References & Citations
[1]5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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