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Iomazenil

CAT: 0804-HY-U00033-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-U00033-01Size:1 mg
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Description
Iomazenil is a benzodiazepine receptor antagonist with partial inverse agonist activity. Iomazenil can assess the binding potential of central benzodiazepine receptors in the cerebral cortex and may reflect neuronal function in viable tissue. Iomazenil use is associated with improved cognitive function in adult patients with ischemic cerebral pathology after indirect revascularization surgery. Iomazenil demonstrated restoration of benzodiazepine receptor binding potential in the affected hemisphere after surgery on brain SPECT imaging[1].
CAS Number
127985-21-1
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/iomazenil.html
Smiles
O=C(C(N=CN1C2=C3C(I)=CC=C2)=C1CN(C)C3=O)OCC
Molecular Formula
C15H14IN3O3
Molecular Weight
411.19
References & Citations
[1]Recovery of Cortical Neurotransmitter Receptor Function and Its Impact on Cognitive Improvement after Indirect Revascularization Surgery Alone for Adult Patients with Ischemic Moyamoya Disease: 123I-Iomazenil Single-Photon Emission Computed Tomography Study
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Iomazenil

Iomazenil is under investigation in clinical trial NCT01590277 (Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans).

CAS Number127985-21-1
PubChem CID10251042
IUPAC Nameethyl 7-iodo-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Molecular FormulaC15H14IN3O3
Molecular Weight411.19
XLogP1.5
Topological Polar Surface Area64.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity461
SMILES
CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC=C3I)C
InChI
InChI=1S/C15H14IN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3
InChIKey
FRIZVHMAECRUBR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Iomazenil
CAS: 127985-21-1
CID: 10251042
Formula: C15H14IN3O3
MW: 411.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight411.19
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass411.00799
Monoisotopic Mass411.00799
Topological Polar Surface Area64.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity461
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T25537-01Iomazenil

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