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Cemsidomide

CAT: 0804-HY-144841-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144841-01Size:5 mg
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Description
Cemsidomide (CFT7455) is a ubiquitin ligase pathway based IKZF1/3 (Ikaros/Aiolos) degrader with molecular glue activity[1]. Cemsidomide has a GI50 of 0.05 nM for NCIH929.1 cells. Cemsidomide is used in the research of multiple myeloma (MM) [1][2].
CAS Number
2504235-67-8
Product Name Alternative
CFT7455
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IKZF Family; Molecular Glues
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cemsidomide.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N([C@]2([H])C(NC(CC2)=O)=O)C3=CC=C(C4=CC=CC1=C43)CC5=CC=C(C=C5)CN6CCOCC6
Molecular Formula
C28H27N3O4
Molecular Weight
469.53
Precautions
H302, H315, H319, H335
References & Citations
[1]David Proia, et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1.|[2]James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement) : LB007.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Cereblon; IKZF1; IKZF3

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