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MIPS521

CAT: 0804-HY-139644-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139644-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MIPS521 is a positive allosteric modulator of adenosine A1 receptor (A1AR) . MIPS521 also has a lower A1R allosteric affinity (pKB=4.95; KB=11 μM) . MIPS521 exhibits pain-relieving effects in vivo through modulation of the increased levels of endogenous adenosine[1][2].
CAS Number
1146188-19-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mips521.html
Purity
98.21
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(N)SC=C1C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=CC=C(C=C3)Cl
Molecular Formula
C19H10ClF6NOS
Molecular Weight
449.80
Precautions
H302, H315, H319
References & Citations
[1]Aurelio L, et, al. Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes. J Med Chem. 2009 Jul 23;52 (14) :4543-7. |[2]Draper-Joyce CJ, et, al. Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature. 2021 Sep;597 (7877) :571-576.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R)

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