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Alprenolol

CAT: 0804-HY-B1517-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1517-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alprenolol ((RS) -Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent[1][2][3].
CAS Number
13655-52-2
Product Name Alternative
(RS) -Alprenolol; dl-Alprenolol
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Alprenolol.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; adjust pH to 7 with 1 M HCL; heat to 60°C) |H2O : < 0.1 mg/mL
Smiles
OC(COC1=CC=CC=C1CC=C)CNC(C)C
Molecular Formula
C15H23NO2
Molecular Weight
249.35
References & Citations
[1]Himori N, et al. Effects of beta-adrenoceptor blocking agents, pindolol, alprenolol and practolol on blood pressure and heart rate in conscious renal hypertensive dogs. Arch Int Pharmacodyn Ther. 1977 Jan;225 (1) :152-65.|[2]Fernández-Guasti A, et al. Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone. Psychopharmacology (Berl) . 1990;101 (3) :354-8.|[3]Parratt JR, et al. Myocardial and haemodynamic effects of the beta-adrenoceptor blocking drug alprenolol (H56/28) in anaesthetized cats. Br J Pharmacol. 1969 Oct;37 (2) :357-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; mLAG-3
Citation 01
Biochemistry. 2025 Aug 19;64 (16) :3585-3598.|bioRxiv. 2020 Jan.|J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Jul 1:1227:123804.|J Pharm Biomed Anal. 2021 Feb 20:195:113870.|Nat Commun. 2020 Sep 25;11 (1) :4857.|Sci Total Environ. 2024 May 13:933:173244.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Nat Chem Biol. 2024 Jan;20 (1) :74-82.

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