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LAP

CAT: 0804-HY-44076-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-44076-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LAP (Lithium phenyl-2,4,6-trimethylbenzoylphosphinate) is a free radical initiator. The free radicals produced by LAP under bioprinting conditions are potentially cytotoxic and mutagenic. In addition, the concentration of LAP affects the mechanical strength of 3D printed scaffolds. Generally, the concentration range of LAP used for curing is 0.05%-1%. The elastic modulus produced at a concentration of 0.1% is the highest, with enhanced mechanical properties and excellent biocompatibility[1][2][3].
CAS Number
85073-19-4
Product Name Alternative
Lithium phenyl-2,4,6-trimethylbenzoylphosphinate
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/lap.html
Purity
99.93
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=P(C(C1=C(C)C=C(C)C=C1C)=O)(C2=CC=CC=C2)O[Li]
Molecular Formula
C16H16LiO3P
Molecular Weight
294.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Nguyen AK, et al. The Photoinitiator Lithium Phenyl (2,4,6-Trimethylbenzoyl) Phosphinate with Exposure to 405 nm Light Is Cytotoxic to Mammalian Cells but Not Mutagenic in Bacterial Reverse Mutation Assays. Polymers (Basel) . 2020 Jul 3;12 (7) :1489.|[2]Qian Feng, et al. "Multi-modal imaging for dynamic visualization of osteogenesis and implant degradation in 3D bioprinted scaffolds." Bioactive Materials 37 (2024) : 119-131.|[3]Nguyen, et al. Toxicity and photosensitizing assessment of gelatin methacryloyl-based hydrogels photoinitiated with lithium phenyl-2, 4, 6-trimethylbenzoylphosphinate in human primary renal proximal tubule epithelial cells. Biointerphases 14.2 (2019) .|[4]Xu H, et al. Effects of Irgacure 2959 and lithium phenyl-2,4,6-trimethylbenzoylphosphinate on cell viability, physical properties, and microstructure in 3D bioprinting of vascular-like constructs. Biomed Mater. 2020 Aug 7;15 (5) :055021.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Biochemical Assay Reagents
Clinical Information
Phase 1

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