MIP-3a Macrophage Inflammatory Protein-3 alpha Mouse Recombinant Protein (CCL20)

• Description:

  Macrophage Inflammatory Protein-3 alpha Mouse Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.9 kDa. The MIP-3a is purified by proprietary chromatographic techniques.

• Synonyms:

  Small inducible cytokine A20 precursor; CCL20; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Liver and activation- regulated chemokine; CC chemokine LARC; Beta chemokine exodus-1; CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; C-C motif chemokine 20; CC chemokine ST38; exodus-1

• Gene Name:

  CCL20

• UniProt:

  O89093

• Reactivity:

  Mouse

• Tissue Specificity:

  Prominently expressed in the small intestine, colon and appendix. Also found in thymus, spleen, lymph node and lung. The long form might be dominant in intestinal, and the short form in lymphoid tissues.

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 95.0% as determined by (a) Analysis by RP-HPLC and (b) Analysis by SDS-PAGE.

• Bioactivity:

  The Activity is calculated by its ability to chemoattract primary human T cells at 2-20ng/ml, corresponding to a specific activity of 50,000-500,000 units/mg.

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  It is recommended to reconstitute the lyophilized MIP-3a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

• Function:

  Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized MIP-3a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL-20 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Please prevent freeze-thaw cycles.

• Other Gene Names:

  C-C motif chemokine 20

• Subcellular Location:

  Secreted.