Anti-DBC1 (3G4) monoclonal CCAR2 Antibody

• Description:

  Boster Bio Anti-DBC1 (3G4) monoclonal CCAR2 Antibody catalog # M03412. Tested in WB, ICC, IP applications. This antibody reacts with Human, Mouse, Rat, Monkey.

• Synonyms:

  Cell cycle and apoptosis regulator protein 2; Cell division cycle and apoptosis regulator protein 2; DBIRD complex subunit KIAA1967; Deleted in breast cancer gene 1 protein; DBC-1; DBC.1; NET35; p30 DBC; CCAR2; DBC1, KIAA1967;

• Gene Name:

  CCAR2

• UniProt:

  Q8N163

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat, Monkey

• Immunogen:

  Synthetic peptide, corresponding to the N-terminus of Human KIAA1967.

• Clonality:

  Monoclonal

• Tissue Specificity:

  Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level) . Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.

• Applications:

  WB, ICC, IP

• Purification:

  The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T) -rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316) . Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560) . Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752) . Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595) . Positively regulates the beta- catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780) . Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920) . Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823) . Represses the transcriptional activator activity of BRCA1 (PubMed:20160719) . Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978) .

• Molecular Weight:

  102902 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Cell cycle and apoptosis regulator protein 2

• Subcellular Location:

  Nucleus

• Protein Name:

  Cell cycle and apoptosis regulator protein 2