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Anti-DAAM2 Antibody

CAT: 0519-A12080Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A12080Size:100 µL
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Description
Boster Bio Anti-DAAM2 Antibody catalog # A12080. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Disheveled-associated activator of morphogenesis 2; DAAM2
Gene Name
DAAM2
UniProt
Q86T65
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human DAAM2.
Clonality
Polyclonal
Tissue Specificity
Expressed in most tissues examined.
Applications
WB, IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1) . Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.
Molecular Weight
123499 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Disheveled-associated activator of morphogenesis 2
Protein Name
Disheveled-associated activator of morphogenesis 2

UniProtKB · Q86T65

Disheveled-associated activator of morphogenesis 2

DAAM2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86T65
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DAAM2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
G5EA45, Q5T4T8, Q5T4U0, Q9NQI5, Q9Y4G0
Protein keywords

Coding sequence diversity

Alternative splicing

Domain

Coiled coil

Disease

Disease variant

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Biological process

Wnt signaling pathway

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