Anti-Ephexin-1 NGEF Antibody

• Description:

  Boster Bio Anti-Ephexin-1 NGEF Antibody catalog # A08935. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Ephexin-1; Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor; NGEF;

• Gene Name:

  NGEF

• UniProt:

  Q8N5V2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human NGEF (NP_062824.2) .

• Clonality:

  Polyclonal

• Tissue Specificity:

  Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.

• Applications:

  WB, IHC, ICC, IF

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) . .

• Molecular Weight:

  82496 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Ephexin-1

• Subcellular Location:

  Cytoplasm . Membrane . Cell projection, growth cone . Associated with membranes. Localizes to axonal growth cones (By similarity) . .

• Protein Name:

  Ephexin-1