Anti-TTC3 Antibody

• Description:

  Boster Bio Anti-TTC3 Antibody catalog # A08132. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  E3 ubiquitin-protein ligase TTC3;2.3.2.27; Protein DCRR1; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3 ; TPR repeat protein D; Tetratricopeptide repeat protein 3; TPR repeat protein 3; TTC3; DCRR1, RNF105, TPRD;

• Gene Name:

  TTC3

• UniProt:

  P53804

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human TTC3

• Clonality:

  Polyclonal

• Tissue Specificity:

  Found in all tissues examined.

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  WB: 1:500-1:2000

• Form:

  Liquid

• Function:

  E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'- polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

• Molecular Weight:

  229869 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  E3 ubiquitin-protein ligase TTC3

• Subcellular Location:

  Nucleus

• Protein Name:

  E3 ubiquitin-protein ligase TTC3