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Anti-EIF3K Antibody

CAT: 0519-A07789-2Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A07789-2Size:100 µL
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Description
Boster Bio Anti-EIF3K Antibody catalog # A07789-2. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Eukaryotic translation initiation factor 3 subunit K
Gene Name
EIF3K
UniProt
Q9UBQ5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 50-100 of Human EIF3K.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous, with the highest levels of expression in brain, testis and kidney.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:1000
Form
Liquid
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815) . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632) . The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773) .
Molecular Weight
25060 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Eukaryotic translation initiation factor 3 subunit K
Subcellular Location
Nucleus
Protein Name
Eukaryotic translation initiation factor 3 subunit K

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