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Anti-IFT57 Antibody

CAT: 0519-A07455Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A07455Size:100 µL
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Description
Boster Bio Anti-IFT57 Antibody catalog # A07455. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Intraflagellar transport protein 57 homolog; Dermal papilla-derived protein 8; Estrogen-related receptor beta-like protein 1; HIP1-interacting protein; MHS4R2; IFT57; DERP8, ESRRBL1, HIPPI;
Gene Name
IFT57
UniProt
Q9NWB7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human IFT57 (NP_060480.1) .
Clonality
Polyclonal
Tissue Specificity
Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Molecular Weight
49108 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Intraflagellar transport protein 57 homolog
Subcellular Location
Cytoplasm, cytoskeleton, cilium basal body . Concentrates within the inner segment of cilia. .
Protein Name
Intraflagellar transport protein 57 homolog

UniProtKB · Q9NWB7

Intraflagellar transport protein 57 homolog

IFT57_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NWB7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IFT57
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q96DA9
Protein keywords

Biological process

ApoptosisTranscriptionTranscription regulation

Cellular component

Cell projectionCiliumCytoplasmCytoskeleton

Disease

Ciliopathy

Domain

Coiled coil

Molecular function

DNA-binding

Technical term

Proteomics identificationReference proteome

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