Anti-Importin-8 IPO8 Antibody

• Description:

  Boster Bio Anti-Importin-8 IPO8 Antibody catalog # A07327. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Importin-8; Imp8; Ran-binding protein 8; RanBP8; IPO8; RANBP8;

• Gene Name:

  IPO8

• UniProt:

  O15397

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human IPO8 (NP_006381.2) .

• Clonality:

  Polyclonal

• Applications:

  WB, ICC, IF

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

• Molecular Weight:

  119938 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Importin-8

• Subcellular Location:

  Cytoplasm . Nucleus .

• Protein Name:

  Importin-8