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Anti-CD8B Antibody

CAT: 0519-A07259Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A07259Size:100 µL
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Description
Boster Bio Anti-CD8B Antibody catalog # A07259. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
T-cell surface glycoprotein CD8 beta chain; CD8b; CD8B; CD8B1;
Gene Name
CD8B
UniProt
P10966
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human CD8B.
Clonality
Polyclonal
Tissue Specificity
Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:1000
Form
Liquid
Function
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs) . In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs) . Additionally, plays a critical role in thymic selection of CD8+ T-cells.
Molecular Weight
23722 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
T-cell surface glycoprotein CD8 beta chain
Subcellular Location
Isoform 1: Cell membrane
Protein Name
T-cell surface glycoprotein CD8 beta chain

UniProtKB · P10966

T-cell surface glycoprotein CD8 beta chain

CD8B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10966
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD8B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
P14860, P14861, Q15980, Q496E0, Q496E1, Q496E2, Q9UDB4, Q9UDB5, Q9UDB6, Q9UDB7, Q9UDB8, Q9UDB9, Q9UDC0, Q9UQ55
Protein keywords

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Technical term

Reference proteome

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