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Anti-CHCHD4 Antibody

CAT: 0519-A07179Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A07179Size:100 µL
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Description
Boster Bio Anti-CHCHD4 Antibody catalog # A07179. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Mitochondrial intermembrane space import and assembly protein 40; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4; CHCHD4; MIA40;
Gene Name
CHCHD4
UniProt
Q8N4Q1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human CHCHD4 (NP_001091972.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues tested, suggesting an ubiquitous expression.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19 and MICU1 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665) . Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS) . Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665) . Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364) . Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864) .
Molecular Weight
15996 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Mitochondrial intermembrane space import and assembly protein 40
Subcellular Location
Mitochondrion intermembrane space
Protein Name
Mitochondrial intermembrane space import and assembly protein 40

UniProtKB · Q8N4Q1

Mitochondrial intermembrane space import and assembly protein 40

MIA40_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8N4Q1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHCHD4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K3Z9, Q96AI2, Q96MY6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Disulfide bond

Cellular component

Mitochondrion

Molecular function

Oxidoreductase

Biological process

Protein transportTranslocationTransport

Domain

Redox-active center

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