Anti-Ksr2 (I694) Antibody

• Description:

  Boster Bio Anti-Ksr2 (I694) Antibody catalog # A06876-1. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Kinase suppressor of Ras 2; hKSR2;2.7.11.1; KSR2;

• Gene Name:

  KSR2

• UniProt:

  Q6VAB6

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide, corresponding to amino acids 662-724 of Human Ksr2.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Mainly expressed in brain and kidney.

• Applications:

  WB, IHC, IF

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro) . Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro) . Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

• Molecular Weight:

  107632 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Kinase suppressor of Ras 2

• Subcellular Location:

  Cytoplasm . Membrane ; Peripheral membrane protein .

• Protein Name:

  Kinase suppressor of Ras 2