RegisterLogin

Anti-SHARPIN Antibody

CAT: 0519-A06687Size: 100 µLDry Ice: NoHazardous: No
CAT#:0519-A06687Size:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Boster Bio Anti-SHARPIN Antibody catalog # A06687. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Sharpin; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; hSIPL1; SHARPIN; SIPL1; PSEC0216;
Gene Name
SHARPIN
UniProt
Q9H0F6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human SHARPIN (NP_112236.3) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. Up-regulated in various tumor tissues such as kidney, liver, ovary and pancreas tumors.
Applications
WB, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Molecular Weight
39949 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Sharpin
Subcellular Location
Cytoplasm, cytosol
Protein Name
Sharpin

Related Products

CatalogName
M06687Anti-SHARPIN Mouse Monoclonal Antibody [Clone ID: OTI1F4]
PROTQ9H0F6SHARPIN (NM_030974) Human Recombinant Protein
LS081858SHARPIN (NM_030974) Human Over-expression Lysate
LS081858-100ugSHARPIN (NM_030974) Human Over-expression Lysate
LS081858-20ugSHARPIN (NM_030974) Human Over-expression Lysate
A02575-1Anti-SHARP2/BHLHE40 antibody
M02575-1Anti-SHARP2/BHLHE40 Antibody (Monoclonal, 35B15)
M04668-1Anti-SHARP1 (BHLHE41) Mouse Monoclonal Antibody [Clone ID: OTI5B1]
M02575Anti-SHARP2 (BHLHE40) Mouse Monoclonal Antibody [Clone ID: OTI10H1]
A09597-2Anti-ANT4/SLC25A31 Antibody

Alternative Products

CatalogName
MBS8291803-01Anti-SHARPIN Antibody
abx126547-01SHARPIN (SHARPIN) Antibody
abx337671-01SHARPIN (SHARPIN) Antibody (FITC)
abx337670-01SHARPIN (SHARPIN) Antibody (HRP)
abx337672-01SHARPIN (SHARPIN) Antibody (Biotin)
MBS1760126-01Anti-SHARPIN Antibody Picoband
TMAB-12759-01Anti-SHARPIN Polyclonal Antibody
SL9581R-01Rabbit Anti-SHARPIN antibody
MBS8501362-01SHARPIN Antibody
YF-PA26676anti-SHARPIN

Popular Products