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Anti-SPPL2A Antibody

CAT: 0519-A06654Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A06654Size:100 µL
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Description
Boster Bio Anti-SPPL2A Antibody catalog # A06654. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Signal peptide peptidase-like 2A
Gene Name
SPPL2A
UniProt
Q8TCT8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human SPPL2A
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014) . Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952) . Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115) . May play a role in the regulation of innate and adaptive immunity (PubMed:16829952) . Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC) -mediated cleavage proteolysis (PubMed:23132852) .
Molecular Weight
58143 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Signal peptide peptidase-like 2A
Subcellular Location
Late endosome membrane
Protein Name
Signal peptide peptidase-like 2A

UniProtKB · Q8TCT8

Signal peptide peptidase-like 2A

SPP2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8TCT8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SPPL2A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SPP-like 2A, SPPL2a
EC number
3.4.23.-
Processing
Precursor
Secondary accessions
B2RDS0, Q8TAW1, Q96SZ8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

EndosomeLysosomeMembrane

PTM

Glycoprotein

Molecular function

HydrolaseProtease

Domain

SignalTransmembraneTransmembrane helix

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