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Anti-PFKL (E724) Antibody

CAT: 0519-A06447-1Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A06447-1Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boster Bio Anti-PFKL (E724) Antibody catalog # A06447-1. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
ATP-dependent 6-phosphofructokinase, liver type
Gene Name
PFKL
UniProt
P17858
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 700-750 of Human PFKL.
Clonality
Polyclonal
Applications
IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
IHC: 1:50-1:200
Form
Liquid
Function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583) . Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity) .
Molecular Weight
85018 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
ATP-dependent 6-phosphofructokinase, liver type
Subcellular Location
Cytoplasm
Protein Name
ATP-dependent 6-phosphofructokinase, liver type

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