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Anti-DAD1 Antibody

CAT: 0519-A06054-1Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A06054-1Size:100 µL
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Description
Boster Bio Anti-DAD1 Antibody catalog # A06054-1. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Oligosaccharyl transferase subunit DAD1; Defender against cell death 1; DAD-1; DAD1;
Gene Name
DAD1
UniProt
P61803
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human DAD1 (NP_001335.1) .
Clonality
Polyclonal
Applications
WB, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc (3) Man (9) GlcNAc (2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853) . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) . All subunits are required for a maximal enzyme activity (By similarity) . Required for the assembly of both SST3A- and SS3B- containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed:22467853) .
Molecular Weight
12497 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein .
Protein Name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

UniProtKB · P61803

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

DAD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61803
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DAD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Oligosaccharyl transferase subunit DAD1
EC number
—
Processing
—
Secondary accessions
D3DS25, O08552, O70364, P46966, P46968, Q6FGA3, Q96GB7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Biological process

Apoptosis

Cellular component

Endoplasmic reticulumMembrane

Domain

TransmembraneTransmembrane helix

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