Anti-EIF3J Antibody

• Description :

  Boster Bio Anti-EIF3J Antibody catalog # A06040-1. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms :

  Eukaryotic translation initiation factor 3 subunit J

• Gene Name :

  EIF3J

• UniProt :

  O75822

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein of human EIF3J (NP_003749.2) .

• Clonality :

  Polyclonal

• Applications :

  WB, ICC, IF

• Purification :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form :

  Liquid

• Function :

  Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815) . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773) .

• Molecular Weight :

  29062 MW

• Shipping Conditions :

  Available

• Storage Conditions :

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names :

  Eukaryotic translation initiation factor 3 subunit J

• Subcellular Location :

  Cytoplasm

• Protein Name :

  Eukaryotic translation initiation factor 3 subunit J