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Anti-RNF5 Antibody

CAT: 0519-A05826Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A05826Size:100 µL
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Description
Boster Bio Anti-RNF5 Antibody catalog # A05826. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
E3 ubiquitin-protein ligase RNF5;2.3.2.27; Protein G16; RING finger protein 5; RING-type E3 ubiquitin transferase RNF5 ; Ram1 homolog; HsRma1; RNF5; G16, NG2, RMA1;
Gene Name
RNF5
UniProt
Q99942
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human RNF5 (NP_008844.1) .
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses.
Molecular Weight
19881 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
E3 ubiquitin-protein ligase RNF5
Subcellular Location
Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
Protein Name
E3 ubiquitin-protein ligase RNF5

UniProtKB · Q99942

E3 ubiquitin-protein ligase RNF5

RNF5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99942
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RNF5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
A2BFI6, B2R4K3, Q0VDB7, Q9UMQ2
Protein keywords

PTM

AcetylationPhosphoprotein

Cellular component

Cell membraneEndoplasmic reticulumMembraneMitochondrion

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Molecular function

Transferase

Domain

TransmembraneTransmembrane helixZinc-finger

Biological process

Ubl conjugation pathway

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