Anti-Sorting nexin-5 SNX5 Antibody

• Description:

  Boster Bio Anti-Sorting nexin-5 SNX5 Antibody catalog # A04788. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Sorting nexin-5; SNX5;

• Gene Name:

  SNX5

• UniProt:

  Q9Y5X3

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human SNX5 (NP_055241.1) .

• Clonality:

  Polyclonal

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  WB: 1:500-1:2000

• Form:

  Liquid

• Function:

  Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns (3P) ) or phosphatidylinositol 3,4-bisphosphate (PtdIns (3,4) P2) (PubMed:15561769) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable) . Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988) . Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235) . May function as link between endosomal transport vesicles and dynactin (Probable) . Plays a role in the internalization of EGFR after EGF stimulation (Probable) . Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387) . Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable) . Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942) . Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941) .

• Molecular Weight:

  46816 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Sorting nexin-5

• Subcellular Location:

  Endosome

• Protein Name:

  Sorting nexin-5