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Anti-Bub3 Antibody

CAT: 0519-A03118-1Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A03118-1Size:100 µL
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Description
Boster Bio Anti-Bub3 Antibody catalog # A03118-1. Tested in WB, ICC, IF, IP, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Mitotic checkpoint protein BUB3; BUB3;
Gene Name
BUB3
UniProt
O43684
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein corresponding to the N-terminus of human Bub3.
Clonality
Polyclonal
Applications
WB, ICC, IF, IP, IHC, Flow Cytometry
Purification
ProA affinity purified
Form
Liquid
Function
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Molecular Weight
37155 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Mitotic checkpoint protein BUB3
Subcellular Location
Nucleus. Chromosome, centromere, kinetochore . Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. .
Protein Name
Mitotic checkpoint protein BUB3

UniProtKB · O43684

Mitotic checkpoint protein BUB3

BUB3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43684
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BUB3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NJ42, B2R6E7, D3DRE9, O43685
Protein keywords

PTM

AcetylationADP-ribosylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell divisionChromosome partitionMeiosisMitosis

Cellular component

CentromereChromosomeKinetochoreNucleus

Technical term

Proteomics identificationReference proteome

Domain

RepeatWD repeat

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