Anti-Sentrin-specific protease 1 SENP1 Antibody

• Description:

  Boster Bio Anti-Sentrin-specific protease 1 SENP1 Antibody catalog # A02156-4. Tested in WB, ICC, IF, IHC, Flow Cytometry applications. This antibody reacts with Human.

• Synonyms:

  Sentrin-specific protease 1;3.4.22.-

• Gene Name:

  SENP1

• UniProt:

  Q9P0U3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant protein within human SENP1 aa 300-500.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.

• Applications:

  WB, ICC, IF, IHC, Flow Cytometry

• Purification:

  ProA affinity purified

• Form:

  Liquid

• Function:

  Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078) . The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240) . Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689) . Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374) . Deconjugates SUMO2 from MTA1 (PubMed:21965678) . Deconjugates SUMO1 from METTL3 (PubMed:29506078) . Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032) . Deconjugates SUMO1 from GPS2 (PubMed:24943844) .

• Molecular Weight:

  73481 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Sentrin-specific protease 1

• Subcellular Location:

  Nucleus

• Protein Name:

  Sentrin-specific protease 1