Anti-NPAS4 Antibody

• Description:

  Boster Bio Anti-NPAS4 Antibody catalog # A02045. Tested in WB applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Neuronal PAS domain-containing protein 4 ; Neuronal PAS4 ; Class E basic helix-loop-helix protein 79 ; bHLHe79 ; HLH-PAS transcription factor NXF

• Gene Name:

  NPAS4

• UniProt:

  Q8IUM7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthetic peptide corresponding to residues in Human NPAS4.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Brain.

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  WB: 1:500-1:1000

• Form:

  Liquid

• Function:

  Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity) . Plays a key role in the structural and functional plasticity of neurons (By similarity) . Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity) . In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity) . In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity) . The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity) . Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity) . Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734) . Can activate the CME (CNS midline enhancer) element (PubMed:14701734) .

• Molecular Weight:

  87117 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Neuronal PAS domain-containing protein 4

• Subcellular Location:

  Nucleus

• Protein Name:

  Neuronal PAS domain-containing protein 4