Anti-HIF-2 Alpha EPAS1 Antibody

• Description:

  Boster Bio Anti-HIF-2 Alpha EPAS1 Antibody catalog # A01248. Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Endothelial PAS domain-containing protein 1; EPAS-1; Basic-helix-loop-helix-PAS protein MOP2; Class E basic helix-loop-helix protein 73; bHLHe73; HIF-1-alpha-like factor; HLF; Hypoxia-inducible factor 2-alpha; HIF-2-alpha; HIF2-alpha; Member of PAS protein 2; PAS domain-containing protein 2; EPAS1; BHLHE73, HIF2A, MOP2, PASD2;

• Gene Name:

  EPAS1

• UniProt:

  Q99814

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.

• Applications:

  WB, IHC, Flow Cytometry

• Purification:

  ProA affinity purified

• Form:

  Liquid

• Function:

  Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity) . Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity) .

• Molecular Weight:

  96459 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Endothelial PAS domain-containing protein 1

• Subcellular Location:

  Nucleus

• Protein Name:

  Endothelial PAS domain-containing protein 1