Anti-C/EBP-Beta (phospho-T235/188) CEBPB Antibody

• Description:

  Boster Bio Anti-C/EBP-Beta (phospho-T235/188) CEBPB Antibody catalog # A01100T235. Tested in WB, IHC applications. This antibody reacts with Human.

• Synonyms:

  CCAAT/enhancer-binding protein beta

• Gene Name:

  CEBPB

• UniProt:

  P17676

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Synthetic phosphopeptide derived from human C/EBP-β around the phosphorylation site of Threonine 235.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed at low levels in the lung, kidney and spleen.

• Applications:

  WB, IHC

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749) . Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity) . During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347) . Essential for female reproduction because of a critical role in ovarian follicle development (By similarity) . Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity) .

• Molecular Weight:

  36106 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  CCAAT/enhancer-binding protein beta

• Subcellular Location:

  Nucleus

• Protein Name:

  CCAAT/enhancer-binding protein beta