Anti-CD63 antigen CD63 Antibody

• Description:

  Boster Bio Anti-CD63 antigen CD63 Antibody catalog # A01080. Tested in WB, IHC applications. This antibody reacts with Human, Rat.

• Synonyms:

  CD63 antigen; Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD63; CD63; MLA1, TSPAN30;

• Gene Name:

  CD63

• UniProt:

  P08962

• Host:

  Rabbit

• Reactivity:

  Human, Rat

• Immunogen:

  Synthetic peptide, corresponding to Human CD63.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Detected in platelets (at protein level) . Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.

• Applications:

  WB, IHC

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.

• Molecular Weight:

  25637 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  CD63 antigen

• Subcellular Location:

  Cell membrane

• Protein Name:

  CD63 antigen