Anti-Cyclin D2 CCND2 Antibody

• Description:

  Boster Bio Anti-Cyclin D2 CCND2 Antibody catalog # A01079. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  G1/S-specific cyclin-D2; CCND2;

• Gene Name:

  CCND2

• UniProt:

  P30279

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human Cyclin D2 (NP_001750.1) .

• Clonality:

  Polyclonal

• Applications:

  WB, IHC, ICC, IF

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity) . .

• Molecular Weight:

  33067 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  G1/S-specific cyclin-D2

• Subcellular Location:

  Nucleus

• Protein Name:

  G1/S-specific cyclin-D2