Anti-ASK1 (phospho-S966) MAP3K5 Antibody

• Description:

  Boster Bio Anti-ASK1 (phospho-S966) MAP3K5 Antibody catalog # A00929S966-1. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Mitogen-activated protein kinase kinase kinase 5;2.7.11.25; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5; MAP3K5; ASK1, MAPKKK5, MEKK5;

• Gene Name:

  MAP3K5

• UniProt:

  Q99683

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic phosphopeptide derived from human ASK1 around the phosphorylation site of Serine 966.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Abundantly expressed in heart and pancreas.

• Applications:

  IHC

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  IHC: 1:50-1:200

• Form:

  Liquid

• Function:

  Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS) . Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs) . Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1) .

• Molecular Weight:

  154537 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Mitogen-activated protein kinase kinase kinase 5

• Subcellular Location:

  Cytoplasm. Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.

• Protein Name:

  Mitogen-activated protein kinase kinase kinase 5