Anti-Myotubularin (Y290) MTM1 Antibody

• Description:

  Boster Bio Anti-Myotubularin (Y290) MTM1 Antibody catalog # A00749Y290. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Myotubularin; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase;3.1.3.95

• Gene Name:

  MTM1

• UniProt:

  Q13496

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide, corresponding to amino acids 256-3111 of Human Myotubularin.

• Clonality:

  Polyclonal

• Applications:

  WB, IHC

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI (3,5) P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070) . Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414) . Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070) . Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508) . Plays a role in mitochondrial morphology and positioning (PubMed:21135508) . Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508) . In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870) .

• Molecular Weight:

  69932 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Myotubularin

• Subcellular Location:

  Cytoplasm

• Protein Name:

  Myotubularin