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Anti-EphB4 (E601) Antibody

CAT: 0519-A00690-2Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A00690-2Size:100 µL
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Description
Boster Bio Anti-EphB4 (E601) Antibody catalog # A00690-2. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Ephrin type-B receptor 4;2.7.10.1; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11; EPHB4; HTK, MYK1, TYRO11;
Gene Name
EPHB4
UniProt
P54760
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human EphB4.
Clonality
Polyclonal
Tissue Specificity
Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix.
Applications
WB, IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
Molecular Weight
108270 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Ephrin type-B receptor 4
Subcellular Location
Cell membrane
Protein Name
Ephrin type-B receptor 4

UniProtKB · P54760

Ephrin type-B receptor 4

EPHB4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P54760
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPHB4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B5A970, B5A971, B5A972, Q7Z635, Q9BTA5, Q9BXP0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Angiogenesis

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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