Anti-ADAM17 Antibody

• Description:

  Boster Bio Anti-ADAM17 Antibody catalog # A00604-3. Tested in WB, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17;3.4.24.86

• Gene Name:

  ADAM17

• UniProt:

  P78536

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

• Applications:

  WB, ICC, IF, IP, Flow Cytometry

• Purification:

  ProA affinity purified

• Form:

  Liquid

• Function:

  Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) . Plays a role in the proteolytic processing of ACE2.

• Molecular Weight:

  93021 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Disintegrin and metalloproteinase domain-containing protein 17

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Protein Name:

  Disintegrin and metalloproteinase domain-containing protein 17