Anti-FANCD2 Antibody

• Description:

  Boster Bio Anti-FANCD2 Antibody catalog # A00563-2. Tested in WB, ICC/IF, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Fanconi anemia group D2 protein; Protein FACD2; FANCD2; FACD;

• Gene Name:

  FANCD2

• UniProt:

  Q9BXW9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein

• Clonality:

  Polyclonal

• Tissue Specificity:

  Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas (at protein level) . Highly expressed in testis, where expression is restricted to maturing spermatocytes.

• Applications:

  WB, ICC, IF, IHC, IP

• Purification:

  ProA affinity purified

• Form:

  Liquid

• Function:

  Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

• Molecular Weight:

  164128 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Fanconi anemia group D2 protein

• Subcellular Location:

  Nucleus

• Protein Name:

  Fanconi anemia group D2 protein