Anti-Interferon regulatory factor 7 IRF7 Antibody

• Description:

  Boster Bio Anti-Interferon regulatory factor 7 IRF7 Antibody catalog # A00115. Tested in WB, ICC/IF, IHC, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat, zebrafish.

• Synonyms:

  Interferon regulatory factor 7; IRF-7; IRF7;

• Gene Name:

  IRF7

• UniProt:

  Q92985

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Zebrafish

• Immunogen:

  Recombinant protein

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed predominantly in spleen, thymus and peripheral blood leukocytes.

• Applications:

  WB, ICC, IF, IHC, IP, Flow Cytometry

• Purification:

  ProA affinity purified

• Form:

  Liquid

• Function:

  Key transcriptional regulator of type I interferon (IFN) -dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

• Molecular Weight:

  54278 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Interferon regulatory factor 7

• Subcellular Location:

  Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.

• Protein Name:

  Interferon regulatory factor 7