Anti-SFRP4 Antibody Picoband®, Cy3 Conjugate

Anti-SFRP4 Antibody Picoband®, Cy3 Conjugate

• Background: Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. It is mappaead to 7p14.1. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. And SFRP4 is a hub gene in a Type 2 Diabetes-associated gene coexpression module in human islets, and reduces glucose-induced insulin secretion through decreased β-cell exocytosis.
• Description: Boster Bio Anti-SFRP4 Antibody catalog # RP1067. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
• Synonyms: Secreted frizzled-related protein 4;sFRP-4;Frizzled protein, human endometrium;FrpHE;SFRP4;FRPHE;
• Gene Name: Secreted frizzled-related protein 4
• Gene ID: 6424
• UniProt: Q6FHJ7
• Host: Rabbit
• Reactivity: Human,Rat
• Cross Reactivity: No cross-reactivity with other proteins
• Immunogen: E.coli-derived human SFRP4 recombinant protein (Position: E140-V346). Human SFRP4 shares 90% and 90.3% amino acid (aa) sequence identity with mouse and rat SFRP4, respectively.
• Clonality: Polyclonal
• Applications: WB
• Purification: Immunogen affinity purified.
• Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
• Form: Lyophilized
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. .
• References & Citations: 1. "Entrez Gene: SFRP4 secreted frizzled-related protein 4". 2. Horvath LG, Lelliott JE, Kench JG et al. (2007). "Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.". Prostate 67 (10): 1081–90.
• Storage Conditions: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
• Calculated Molecular Weight: 39827 MW
• Observed Molecular Weight: 40 kDa
• Fragment: Rabbit IgG
• Specificity: No cross reactivity with other proteins.
• Applications Notes: Western blot, 0.1-0.5μg/ml, Human, Rat