Mouse Interleukin-1 Alpha, Il1a Primacu™ ELISA Kit

Mouse Interleukin-1 Alpha, Il1a Primacu™ ELISA Kit

• Background: IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6, and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
• Description: Interleukin-1 alpha
• Gene Name: Il1a
• Gene ID: 16175
• UniProt: P01582
• Origin Species: Mouse
• Reactivity: Mouse
• Target: IL-1 alpha
• Field of Research: Neuroscience,Immunology,Metabolism,Cancer,Stem cells
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 4 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 6.25-400 pg/mL
• Sensitivity: 1.28 pg/mL
• Weight: 31023
• Storage Temperature: 2-8°C