Human Interleukin-1 Receptor-Like 1, IL1RL1 Primacu™ ELISA Kit

Human Interleukin-1 Receptor-Like 1, IL1RL1 Primacu™ ELISA Kit

• Background: IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.
• Description: Interleukin-1 receptor-like 1
• Synonyms: DER4;ST2;T1
• Gene Name: IL1RL1
• Gene ID: 9173
• UniProt: Q01638
• Origin Species: Human
• Reactivity: Human
• Target: ST2
• Field of Research: Immunology,Cardiovascular
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 5 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 7.8-500 pg/mL
• Sensitivity: 1.87 pg/mL
• Weight: 63358
• Storage Temperature: 2-8°C