Mouse Interleukin-18, Il18 Primacu™ ELISA Kit

Mouse Interleukin-18, Il18 Primacu™ ELISA Kit

• Background: Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1-like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cell -, IL-4- and STAT6-dependent fashion. IL-18 and T cell receptor-mediated stimulation could induce naive CD4+ T cells to develop into IL-4-producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in the regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feedback to promote Th1 cell development in the synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
• Description: Interleukin-18
• Synonyms: Igif
• Gene Name: Il18
• Gene ID: 16173
• UniProt: P70380
• Origin Species: Mouse
• Reactivity: Mouse
• Target: IL-18
• Field of Research: Neuroscience,Cancer,Immunology,Metabolism
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 30 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 46.88-3000 pg/mL
• Sensitivity: 9.14 pg/mL
• Weight: 22135
• Storage Temperature: 2-8°C