Human Mhc Class I Polypeptide-Related Sequence B, MICB Primacu™ ELISA Kit

Human Mhc Class I Polypeptide-Related Sequence B, MICB Primacu™ ELISA Kit

• Background: MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without the capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+αβ T cells, and γδ T cells on which the receptor is expressed. MICA/B is minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases.
• Description: MHC class I polypeptide-related sequence B
• Synonyms: PERB11.2
• Gene Name: MICB
• Gene ID: 4277
• UniProt: Q29980
• Origin Species: Human
• Reactivity: Human
• Target: MICB
• Field of Research: Immunology
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 50 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 78.12-5000 pg/mL
• Sensitivity: 24.49 pg/mL
• Weight: 42575
• Storage Temperature: 2-8°C