Mouse Phospholipase A2, Pla2g1b Primacu™ ELISA Kit

Mouse Phospholipase A2, Pla2g1b Primacu™ ELISA Kit

• Background: phospholipase A2, also known as Phosphatidylcholine 2-acylhydrolase 1B, Group IB phospholipase A2, PLA2 and PLA2G1B, is a secreted protein that belongs to the phospholipase A2 family. Phospholipase A2 / PLA2G1B catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic Phospholipase A2 / PLA2G1B enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of Phospholipase A2 / PLA2G1B have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets. Mice lacking in Phospholipase A2 / PLA2G1B are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. Oral supplementation of a diabetogenic diet with the PLA2G1B inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes. PLA2G1B inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
• Description: Phospholipase A2
• Synonyms: Pla2
• Gene Name: Pla2g1b
• Gene ID: 18778
• UniProt: Q9Z0Y2
• Origin Species: Mouse
• Reactivity: Mouse
• Target: PLA2G1B
• Field of Research: Signal transduction,Metabolism
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 2 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 3.125-200 pg/mL
• Sensitivity: 0.96 pg/mL
• Weight: 16290
• Storage Temperature: 2-8°C